Stonefish are the world’s most venomous fish. This title is owed to the infamously deleterious toxin housed within their dorsal spines that is designed to cause extreme pain to predators. However, what is less well-known is that stonefish also harness a second type of toxin, a poison called ichthyocrinotoxin, that they secrete through the wart-like nodules that span their epidermis. Stonefish ichthyocrinotoxins are known to be completely different to their venom in both composition, as well as their proposed ecological function. Stonefish ichthyocrinotoxins also appear to be vastly different between species. This talk aims to outline what these differences are, and why they might be occurring from an ecological perspective.