Industrialised exploitation of the global ocean, including areas beyond national jurisdiction, has had major impacts on marine life with population declines common across taxa. Continued expansion of economic developments linking growth with ocean sustainability is at the forefront of the current United Nations (UN) Decade of Ocean Science and of the Sustainable Development Goal 14. However, there is a clear mismatch between the intensifying global footprint of anthropogenic threats and the limited existing protection of marine megafauna, which are more threatened by extinction than any other vertebrate species. Addressing this mismatch is challenging, as marine megafauna can travel 1000s of km annually crossing multiple jurisdictions. A global, multi-disciplinary scientific program is needed to reveal real overlaps between animal space-use and anthropogenic activities. This is one of the aims of MegaMove, a global project endorsed by the UN Ocean Decade and involving a concerted network of collaborators from around the globe. MegaMove aims to compile and analyse big datasets on animal movement and to implement an already designed framework to create a resource for interoperable and standardised biologging data sharing and querying. Ultimately, such resource will assist creating a tool for dynamic prediction of marine megafauna occurrence, ecologically significant areas, and map risk at global scale.