Outbreaks of crown-of-thorns starfish (COTS) are a major driver of coral decline across the Great Barrier Reef (GBR) and compound upon the impacts of increasingly frequent and severe coral bleaching events and cyclones. The primary objective of the COTS Control Program is to suppress outbreaks and protect coral at focal reefs and across regions through strategic management action. The Program was established in 2012 following the initiation of the current outbreak and it has progressively improved and expanded over the past decade to effectively and efficiently manage COTS outbreaks and protect coral across entire reefs and regions. The Program is underpinned by data-driven decision support tools and the best-available knowledge, to prioritise and target reefs for COTS management, and to optimally deploy surveillance and cull effort. It is the largest-scale intervention program on the GBR today and it builds upon and strengthens foundational management actions, including Marine Park Zoning. The Control Program actively partners with the research community and key stakeholders, to continuously improve and achieve greater outcomes for the health and resilience of the Great Barrier Reef. In this presentation we will highlight Program insights, outcomes and knowledge gaps from a management perspective.