The coral-eating starfish Achanthaster planci, continues to be one of the main contributors to coral cover loss globally. Until the predominant underlying causes of population explosions have been positively identified and adequately addressed, local culling efforts has been recognized as the current most effective means of controlling unsustainable population numbers. To aid in these efforts our research is focused on using multi-omics approaches together with behaviour analysis, to identify olfactory semiochemicals released from the starfish and its prey (coral), particularly in situations where attraction, feeding and aggregation behaviours have been observed. By this research, we have significantly advanced our current knowledge related to the relevant semiochemicals, including novel proteins. The outcomes should pave the way for future developments in starfish biocontrol.